I have been using Trans-Os cervical sampler brush for about a year now. It makes pap smear procedure much faster and therefore better tolerated by patients. Most importantly, I feel that it improves a collection of tissue for pathology by using a plastic cover over the brush system to preserve the collected material and not loose any of it during a transport into a bottle. It also avoids contamination during a transport onto the bottle. It gives me optimal results in early detection of dysplasia.

The sampler brush is an ultimate tool in efficient collections of cervical and endocervical cells.

Raisa Howard C.N.P.


"I have reviewed these materials from my position as a pathologist of approximately thirty years experience with the daily interpretation of cytology specimens and a sense of logic derived from that experience.

I believe the concept you present has definite potential to improve the harvest of cells representative of the critical micro-anatomic region of the uterine cervix that is usually the area in which the cellular abnormalities of cancer and its pre-cancer lesions originate."

Read entire letter from Louis H. Weiland, M.D.

Gynemed LLC

Endocervix and Ectocervix

Gary W. Gill, CT (ASCP) CFIAC
Cytotechnological Consultant
December 2004


Used as intended-and as demonstrated in pilot studies, the Gynemed LLC Pap collection device can be expected to enhance the usefulness of cervical cytology specimens as follows:

  • Minimizes differences in smear taking technique among professionals.
  • Displaces cervical plug, reducing the amount of non-cellular material collected.
  • Patients experience less discomfort and hemorrhage, and thus producing fewer limited/unsatisfactory samples due to obscuring blood.
  • The controlled sampling length reduces the likelihood of sampling the lower uterine segment, which contains unfamiliar cells that may confound morphologic interpretation.
  • Endocervical cell sampling is improved as evidenced by the presence of numerous recognizable groups of endocervical cells in all specimens from women with a cervix. While the absence of endocervical cells is less significant in the 2001 Bethesda System terminology for reporting results of cervical cytology than it was in the 1991 version, clinicians do not want to see such “no EC” results reported to them. Clinicians associate the absence of endocervical cells as evidence of poor smear taking and the potential risk of increased risk of a false negative result for which they might be held accountable. Some clinicians will recall patients whose Pap tests did not include endocervical cells for repeat Pap tests.
  • Higher yield of atypical cells by letter samplins as S/C Junction, reducing sampling error non-correlations.
  • Higher cellularity and better removal of cellular material from the collection device, which should produce fewer sampling-based false negative Pap test results.

Read entire Independant Study

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